Department of Microbiology, Islamic Azad University, Tehran East Branch, Tehran, Iran.
10.22034/atj.2026.250917
Abstract
Engineered regulatory T cells (Tregs) represent a promising precision immunotherapy for autoimmune diseases by restoring immune tolerance while limiting broad immunosuppression. As emphasized in the uploaded review, the major therapeutic challenge is Treg instability in inflamed environments, where loss of FoxP3 fidelity can reduce suppressive function and even promote pathogenic behavior. Recent advances in genetic engineering, CAR-Treg design, and synthetic biology are making it possible to generate Tregs with improved antigen specificity, stability, and tissue-targeted activity. Together, these approaches position engineered Tregs as a next-generation adoptive cell therapy with the potential to achieve durable immune regulation in complex autoimmune disorders.
Pourmand,P . (2026). Engineered Regulatory T Cells (Tregs): A Novel Frontier in the Treatment of Autoimmune Diseases. Advanced Therapies Journal, 8(27), 34-40. doi: 10.22034/atj.2026.250917
MLA
Pourmand,P . "Engineered Regulatory T Cells (Tregs): A Novel Frontier in the Treatment of Autoimmune Diseases", Advanced Therapies Journal, 8, 27, 2026, 34-40. doi: 10.22034/atj.2026.250917
HARVARD
Pourmand P. (2026). 'Engineered Regulatory T Cells (Tregs): A Novel Frontier in the Treatment of Autoimmune Diseases', Advanced Therapies Journal, 8(27), pp. 34-40. doi: 10.22034/atj.2026.250917
CHICAGO
P Pourmand, "Engineered Regulatory T Cells (Tregs): A Novel Frontier in the Treatment of Autoimmune Diseases," Advanced Therapies Journal, 8 27 (2026): 34-40, doi: 10.22034/atj.2026.250917
VANCOUVER
Pourmand P. Engineered Regulatory T Cells (Tregs): A Novel Frontier in the Treatment of Autoimmune Diseases. Advanced Therapies Journal. 2026;8(27):34-40. doi: 10.22034/atj.2026.250917
