Advanced Therapies Journal

Advanced Therapies Journal

Dynamic Biomaterials: The Next Generation of Regenerative Therapies

Reviewers

Author
Department of Biology, East Branch of Azad University, Tehran, Iran.
10.22034/atj.2025.518661.1011
Abstract
Live materials signify a transformative shift in regenerative medicine, offering a dynamic and interactive methodology for tissue repair and regeneration by merging the structural benefits of biomaterials with the inherent biological functions of live cells. These composite materials, produced through many advanced techniques like cell encapsulation, scaffold-based procedures, layer-by-layer assembly, and 3D bioprinting, enable the creation of customized structures tailored to specific therapeutic needs. This tailored methodology is bolstered by advancements in microfluidics and the development of organ-on-a-chip and organoid techniques, facilitating the creation of patient-derived tissue and organ models for drug assessment and therapeutic enhancement. Despite existing challenges in translating these promising innovations into widespread clinical application, ongoing research and development in biomaterials, microfabrication, and our understanding of cell-material interactions are rapidly progressing. This article intends to provide a comprehensive analysis of the current status of living materials, exploring the diverse engineering methodologies employed in their design and fabrication, highlighting their extensive potential for regenerative medicine, and discussing the existing challenges and promising opportunities within this transformative domain.
Keywords

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  • Receive Date 25 April 2025
  • Revise Date 16 May 2025
  • Accept Date 22 May 2025