Advanced Therapies Journal

Advanced Therapies Journal

Approaches to Traditional Vaccines and the Development of New Person-Centered Vaccines

Reviewers

Authors
1 Department of Genetics, Faculty of Basic Sciences, Shahrekord Islamic Azad University, Shahrekord, Iran.
2 Department of Biology, Faculty of Basic Sciences, East Tehran Branch, Islamic Azad University, Tehran, Iran.
10.22034/atj.2024.210460
Abstract
A vaccine is a biological product that specifically leads to acquired immunity against a pathogenic pathogen and prevents the disease in the face of the main pathogen in a person. Therefore, vaccines are an important tool for maintaining health in the global community. Traditional vaccines have been used against a wide range of pathogenic pathogens, both viral and bacterial, and have been successful. However, these vaccines do not work and are ineffective against pathogens that change rapidly in terms of genetic material and surface epitopes. 
During the last decade, vaccines based on nucleic acids, viral vectors and biomaterials have shown promising results. This study has discussed an overview of traditional vaccines, mRNA-based vaccines, viral vector-based vaccines, and biomaterials.
Keywords

1.Organization, W.H., Health topics. Vaccines. 2019.
2.Orenstein, W.A. and R. Ahmed, Simply put: Vaccination saves lives. 2017, National Acad Sciences. p. 4031-4033.
3.Gebre, M.S., et al., Novel approaches for vaccine development. Cell, 2021. 184(6): p. 1589-1603.
4.Pandey, A. and A.P. Galvani, The global burden of HIV and prospects for control. The Lancet HIV, 2019. 6(12): p. e809-e811.
5.Riedel, S. Edward Jenner and the history of smallpox and vaccination. in Baylor University medical center proceedings. 2005. Taylor & Francis.
6.Demento, S.L., et al., Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype. Biomaterials, 2012. 33(19): p. 4957-4964.
7.Tsoras, A.N. and J.A. Champion, Protein and peptide biomaterials for engineered subunit vaccines and immunotherapeutic applications. Annual Review of Chemical and Biomolecular Engineering, 2019. 10: p. 337-359.
8.Black, M., et al., Self‐assembled peptide amphiphile micelles containing a cytotoxic T‐cell epitope promote a protective immune response in vivo. Advanced Materials, 2012. 28(24): p. 3845-3849.
9.Vajdy, M., Immunomodulatory properties of vitamins, flavonoids and plant oils and their potential as vaccine adjuvants and delivery systems. Expert opinion on biological therapy, 2011. 11(11): p. 1501-1513.
10.Yang, L., et al., Design of nanomaterial based systems for novel vaccine development. Biomaterials science, 2016. 4(5): p. 785-802.
11.Irvine, D.J., M.A. Swartz, and G.L. Szeto, Engineering synthetic vaccines using cues from natural immunity. Nature materials, 2013. 12(11): p. 978-990.
12.Welch, R.P., et al., Protein–polymer delivery: Chemistry from the cold chain to the clinic. Bioconjugate Chemistry, 2018. 29(9): p. 2867-2883.
13.Bartok, E. and G. Hartmann, Immune sensing mechanisms that discriminate self from altered self and foreign nucleic acids. Immunity, 2020. 53(1): p. 54-77.
14.Stewart, J. and D. Weir, Innate and acquired immunity. Medical Microbiology, edited by Greenwood D. New York: Churchill Livingstone, 2012: p. 109-135.
15.Barouch, D.H. and L.J. Picker, Novel vaccine vectors for HIV-1. Nature Reviews Microbiology, 2014. 12(11): p. 765-771.
16.Champion, C.R., Heplisav-B: a hepatitis B vaccine with a novel adjuvant. Annals of Pharmacotherapy, 2021. 55(6): p. 783-791.
17.Vartak, A. and S.J. Sucheck, Recent advances in subunit vaccine carriers. Vaccines, 2016. 4(2): p. 12.
18.Kheirvari, M., H. Liu, and E. Tumban, Virus-like particle vaccines and platforms for vaccine development. Viruses, 2023. 15(5): p. 1109.
19.Bachmann, M.F. and G.T. Jennings, Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nature Reviews Immunology, 2010. 10(11): p. 787-796.
20.Chackerian, B., M.R. Durfee, and J.T. Schiller, Virus-like display of a neo-self antigen reverses B cell anergy in a B cell receptor transgenic mouse model. The Journal of Immunology, 2008. 180(9): p. 5816-5825.
21.Yuseff, M.-I., et al., How B cells capture, process and present antigens: a crucial role for cell polarity. Nature Reviews Immunology, 2013. 13(7): p. 475-486.
22.Zabel, F., T.M. Kündig, and M.F. Bachmann, Virus-induced humoral immunity: on how B cell responses are initiated. Current opinion in virology, 2013. 3(3): p. 357-362.
23.Pardi, N., M.J. Hogan, and D. Weissman, Recent advances in mRNA vaccine technology. Current opinion in immunology, 2020. 65: p. 14-20.
24.Schlake, T., et al., Developing mRNA-vaccine technologies. RNA biology, 2012. 9(11): p. 1319-1330.
25.Suschak, J.J., J.A. Williams, and C.S. Schmaljohn, Advancements in DNA vaccine vectors, non-mechanical delivery methods, and molecular adjuvants to increase immunogenicity. Human vaccines & immunotherapeutics, 2017. 13(12): p. 2837-2848.
26.Pardi, N., et al., In vitro transcription of long RNA containing modified nucleosides. Synthetic Messenger RNA and Cell Metabolism Modulation: Methods and Protocols, 2013: p. 29-42.
27.Weissman, D., et al., HPLC purification of in vitro transcribed long RNA. Synthetic messenger RNA and cell metabolism modulation: Methods and protocols, 2013: p. 43-54.
28.Karikó, K., et al., Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA. Nucleic acids research, 2011. 39(21): p. e142-e142.
29.Thess, A., et al., Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals. Molecular Therapy, 2015. 23(9): p. 1456-1464.
30.Sahin, U., K. Karikó, and Ö. Türeci, mRNA-based therapeutics—developing a new class of drugs. Nature reviews Drug discovery, 2014. 13(10): p. 759-780.
31.Pardi, N., et al., mRNA vaccines—a new era in vaccinology. Nature reviews Drug discovery, 2018. 17(4): p. 261-279.
32.Kowalski, P.S., et al., Delivering the messenger: advances in technologies for therapeutic mRNA delivery. Molecular Therapy, 2019. 27(4): p. 710-728.
33.Verbeke, R., et al., The dawn of mRNA vaccines: The COVID-19 case. Journal of Controlled Release, 2021. 333: p. 511-520.
34.John, S., et al., Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity. Vaccine, 2018. 36(12): p. 1689-1699.
35.Espeseth, A.S., et al., Modified mRNA/lipid nanoparticle-based vaccines expressing respiratory syncytial virus F protein variants are immunogenic and protective in rodent models of RSV infection. npj Vaccines, 2020. 5(1): p. 16.
36.Lemarchand, P., et al., Adenovirus-mediated transfer of a recombinant human alpha 1-antitrypsin cDNA to human endothelial cells. Proceedings of the National Academy of Sciences, 1992. 89(14): p. 6482-6486.
37.Sakurai, F., M. Tachibana, and H. Mizuguchi, Adenovirus vector-based vaccine for infectious diseases. Drug Metabolism and Pharmacokinetics, 2022. 42: p. 100432.
38.Hage, E., et al., Human mastadenovirus type 70: a novel, multiple recombinant species D mastadenovirus isolated from diarrhoeal faeces of a haematopoietic stem cell transplantation recipient. Journal of General Virology, 2015. 96(9): p. 2734-2742.
39.Usman, N. and M. Suarez, Adenoviruses. 2020.
40.    Luzuriaga, M.A., et al., Biomaterials and nanomaterials for sustained release vaccine delivery. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021. 13(6): p. e1735.
41.Shen, Y., et al., Applications and perspectives of nanomaterials in novel vaccine development. MedChemComm, 2018. 9(2): p. 226-238.
42.Uppu, D.S., et al., Temporal release of a three-component protein subunit vaccine from polymer multilayers. Journal of controlled release, 2020. 317: p. 130-141.
43.Elmowafy, E.M., M. Tiboni, and M.E. Soliman, Biocompatibility, biodegradation and biomedical applications of poly (lactic acid)/poly (lactic-co-glycolic acid) micro and nanoparticles. Journal of Pharmaceutical Investigation, 2019. 49: p. 347-380.
44.Sahdev, P., L.J. Ochyl, and J.J. Moon, Biomaterials for nanoparticle vaccine delivery systems. Pharmaceutical research, 2014. 31: p. 2563-2582.
45.Bachelder, E.M., et al., Acetal-derivatized dextran: an acid-responsive biodegradable material for therapeutic applications. Journal of the American Chemical Society, 2008. 130(32): p. 10494-10495.
46.Huang, C.-H., et al., Degradable emulsion as vaccine adjuvant reshapes antigen-specific immunity and thereby ameliorates vaccine efficacy. Scientific Reports, 2016. 6(1): p. 36732.
47.Lou, P.J., et al., PMMA particle‐mediated DNA vaccine for cervical cancer. Journal of Biomedical Materials Research Part A: An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials, 2009. 88(4): p. 849-857.
48.Men, Y., et al., Induction of a cytotoxic T lymphocyte response by immunization with a malaria specific CTL peptide entrapped in biodegradable polymer microspheres. Vaccine, 1997. 15(12-13): p. 1405-1412.
49.Lü, J.-M., et al., Current advances in research and clinical applications of PLGA-based nanotechnology. Expert review of molecular diagnostics, 2009. 9(4): p. 325-341.
50.Silva, A., et al., PLGA particulate delivery systems for subunit vaccines: Linking particle properties to immunogenicity. Human vaccines & immunotherapeutics, 2016. 12(4): p. 1056-1069.
51.Nagpal, P.S., et al., Aerosol immunization by alginate coated mycobacterium (BCG/MIP) particles provide enhanced immune response and protective efficacy than aerosol of plain mycobacterium against M. tb. H37Rv infection in mice. BMC Infectious Diseases, 2019. 19: p. 1-14.
52.Sarei, F., et al., Alginate nanoparticles as a promising adjuvant and vaccine delivery system. Indian Journal of Pharmaceutical Sciences, 2013. 75(4): p. 442.
53.Wang, H. and M. Roman, Cellulose-based oral vaccine formulation for influenza virus. Nanomedicine: Nanotechnology, Biology and Medicine, 2016. 2(12): p. 489.
54.Harde, H., A.K. Agrawal, and S. Jain, Development of stabilized glucomannosylated chitosan nanoparticles using tandem crosslinking method for oral vaccine delivery. Nanomedicine, 2014. 9(16): p. 2511-2529.
55.Bussio, J.I., C. Molina-Perea, and J.V. González-Aramundiz, Hyaluronic acid nanocapsules as a platform for needle-free vaccination. Pharmaceutics, 2019. 11(5): p. 246.
56.Rydell, N., L. Stertman, and I. Sjöholm, Starch microparticles as vaccine adjuvant. Expert Opinion on Drug Delivery, 2005. 2(5): p. 807-828.
57.Chung, Y.H., et al., COVID-19 vaccine frontrunners and their nanotechnology design. ACS nano, 2020. 14(10): p. 12522-12537.
58.Fries, C.N., et al., Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health. Nature Nanotechnology, 2021. 16(4): p. 1-14.
59.McCann N, O’Connor D, Lambe T, Pollard AJ. Viral vector vaccines. Current Opinion in Immunology. 2022 Aug 1;77:102210.
60.Gharaghie TP, Beiranvand S, Abbas Doosti AH, Ghadiri SH. A review of the epidemiology and clinical signs of SARS-COV-2. NCMB J. 2020;11(41):103-20.
61.Ghourchian H, Pecho RD, Karimi-Dehkordi M, Mazandarani A, Ghajari G, Piri-Gharaghie T. Novel niosome-encapsulated 2, 5-Diketopiperazine (BHPPD): synthesis, formulation, and anti-breast cancer activity. Applied Biochemistry and Biotechnology. 2024 Jun;196(6):3126-47.
62.Piri Gharaghie T, Beiranvand S, Ghadiri A, Hajimohammadi S. A Review of Bioinformatics Studies on the Function of Structural and Nonstructural Proteins and the Level of Glycoprotein Inhibiting Heme Metabolism by SARS-CoV-2 Virus. Jundishapur Scientific 63Medical Journal. 2022 May 22;21(2):176-93.
63.Ghajari G, Moosavi R. Evaluation of the effects of diazinon toxin on some reproductive parameters in male rats. Personalized Medicine Journal. 2022 Jun 20;7(25):30-5.
Volume 6, Issue 21
Autumn 2024
Pages 52-58

  • Receive Date 23 October 2024
  • Revise Date 10 November 2024
  • Accept Date 19 November 2024