Neutrophils have gained significant interest in recent years due to their ability to promote malignancy. A high neutrophil-to-lymphocyte ratio is seen as a prognostic marker for cancer patients. Neutrophils are now recognized as immunological cells of the innate immune system that have several functions and are actively involved in the pathological process of cancer, rather than being just spectators. Their wide range of variations and adaptability are becoming more and more acknowledged. This review provides a concise overview of prior research investigating the functions and processes of neutrophils in the onset, advancement, spread, and recurrence of cancer. We provide a general overview of many studies that examine the characteristics and roles of neutrophils associated with tumors. Additionally, we discuss the formation of neutrophil extracellular traps, which are web-like structures produced by neutrophils that contribute to the advancement of cancer. Furthermore, we explore the interactions between neutrophils and the tumor microenvironment. Furthermore, several focused research on therapeutic neutrophils have achieved notable advancements and shown promising approaches for cancer therapy.