Reviewers
Authors
1 Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
2 Department of biology, Faculty of science, Mashhad branch, Islamic Azad University, Mashhad, Iran
Abstract
Colorectal cancer (CRC) is a very prevalent kind of cancer that is regularly diagnosed on a global scale. The lifestyle is recognized as a significant risk factor for CRC, particularly in cases of sporadic colorectal cancer. The gut microbiota undergoes significant alterations in its natural composition over the first ten years of life. Ensuring homeostasis in the gut is crucial because the structural and metabolic activities of the commensal microbiota prevent the colonization of pathogens in the intestines. Dysbiosis, which refers to an abnormality in the function or structure of the intestinal microbiota, has been linked to several disorders, including CRC. Without a doubt, some probiotics, when correctly prescribed and given, may effectively restore balance to the gut microbiota. This might potentially have a beneficial impact on immunological regulation in the gastrointestinal tract and reduce inflammation of the intestinal lining. New research strongly supports the concept that regular use of certain probiotics might be a practical method to successfully shield patients from the potentially harmful effects of radiation treatment or chemotherapy. Conversely, emerging therapeutic methods known as personalized medicine have provided a fresh perspective in the field of medical science. The correlation between microbiome and personalized medicine has emerged as a particularly intriguing area of further study, with significant implications for the treatment of diseases like cancer. This study aims to investigate the potential relationship between dysbiosis in the intestinal microbiota and colorectal cancer, as well as the possible involvement of probiotics in the improvement of colon cancer. Also, the relationship between personal medicine and intestinal microbiome in the development of various diseases related to the intestine has been mentioned.
Keywords
)