Reviewers
Authors
1 Department of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, Iran.
2 Department of Biology, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Abstract
The advancements in immuno-oncology have created a new and unparalleled opportunity for the advancement of vaccination methods. Therapeutic DNA cancer vaccines are now regarded as an excellent way to stimulate the immune system in its fight against cancer. Lung cancer is well recognized as one of the primary factors leading to patient mortality worldwide. Despite significant advancements in innovative tumor immunotherapy, including the use of immune checkpoint inhibitors or oncolytic viruses, the overall 5-year survival rate of individuals with lung malignancies remains very low. Therefore, there is an urgent need to find efficacious vaccinations for the treatment of lung cancer. DNA vaccines are now regarded as a viable immunotherapy approach to stimulate the host immune system against lung cancer. First, we discuss antigen repertoire selection and delivery strategies to improve cancer vaccines. We summarize the recent advances in DNA vaccines that target lung cancer antigens and highlight their implications for disease treatment.
Keywords
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